hypothesis-generation

預期結果:

• Hypothesis 1 (Blue): Tumor mutational burden determines response - patients with high TMB have more neoantigens that immune cells can recognize
• Hypothesis 2 (Green): T-cell inflamed microenvironment - pre-existing T-cell infiltration indicates receptive immune environment
• Hypothesis 3 (Purple): Microbiome composition - specific gut bacteria enhance checkpoint inhibitor efficacy
• Key prediction: If microbiome hypothesis is correct, fecal transplant from responders should transfer responsiveness
• Discriminating experiment: Compare gene expression profiles of responders vs non-responders to identify signature

預期結果:

• Hypothesis 1 (Deep Blue): Deep root system access - superior water retrieval from lower soil layers during drought periods
• Hypothesis 2 (Forest Green): Stomatal regulation efficiency - enhanced leaf-level water conservation through rapid stomatal closure
• Hypothesis 3 (Royal Purple): Osmotic adjustment capacity - cellular solute accumulation maintains turgor under water stress
• Testable prediction: Deep root hypothesis predicts positive correlation between root depth and survival rate under drought
• Experimental design: Controlled drought trial with root imaging to measure depth correlation